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Spautin-1 (b)
CAS No. 1262888-28-7
Spautin-1 (b)( Spautin1 )
Catalog No. M11101 CAS No. 1262888-28-7
Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
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| 5MG | 43 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 103 | In Stock |
|
| 50MG | 186 | In Stock |
|
| 100MG | 332 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSpautin-1 (b)
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NoteResearch use only, not for human use.
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Brief DescriptionSpautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM.
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DescriptionSpautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14; promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity; promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence of MG132; sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib).
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In Vitro——
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In Vivo——
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SynonymsSpautin1
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorUSP10|USP13
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1262888-28-7
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Formula Weight271.271
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Molecular FormulaC15H11F2N3
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Purity>98% (HPLC)
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SolubilityDMSO: 27.1 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESFC1=CC=C(CNC2=C3C=C(F)C=CC3=NC=N2)C=C1
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Chemical Name6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu J, et al. Cell. 2011 Sep 30;147(1):223-34.
2. Li Y, et al. Nat Commun. 2017 Jun 1;8:15752. doi: 10.1038/ncomms15752.
3. Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21.
4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1;27(15):1718-30.
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